Science Daily March 3, 2022
A team of researchers in the US (University of Illinois, UMass Amherst, Stanford University) expanded molecular alphabet for DNA data storage comprising four natural and seven chemically modified nucleotides that are readily detected and distinguished using nanopore sequencers. They showed that Mycobacterium smegmatis porin A (MspA) nanopores can accurately discriminate 77 combinations and orderings of chemically diverse monomers within homo- and heterotetrameric sequences. The sequencing accuracy exceeded 60%. The extended molecular alphabet may potentially offer a nearly 2-fold increase in storage density and potentially the same order of reduction in the recording latency, thereby enabling new implementations of molecular recorders…read more. Open Access TECHNICAL ARTICLE
Graphical abstract. Credit: Nano Lett. 2022, XXXX, XXX, XXX-XXX, February 25, 2022Â