Vaccine shows signs of protection against dozen-plus flu strains

Science Daily  March 3, 2021 Influenza A virus infection in swine impacts the agricultural industry in addition to its zoonotic potential. A team of researchers in the US (University of Nebraska, St. Jude’s Children’s Hospital, TN, Los Alamos National Laboratory) designed a universal swine H3 influenza vaccine using epigraph, a computational algorithm. The epigraph hemagglutinin proteins were delivered using an Adenovirus type 5 vector and compared to a wild type of hemagglutinin and the commercial inactivated vaccine, FluSure. In mice, epigraph vaccination leads to significant cross-reactive antibody and T-cell responses against a diverse panel of swH3 isolates. Epigraph vaccination also […]