SciTech Daily  January 6, 2023 Diverse DNA-deforming processes are impacted by the local mechanical and structural properties of DNA, which in turn depend on local sequence and epigenetic modifications. Deciphering the mechanical code which impacts the diverse deforming processes has been a challenge. Utilizing high-throughput measurements of DNA bendability an international team of researchers (UK, USA – Johns Hopkins University, Howard Hughes Medical Institute, Spain) quantitatively established how the occurrence and spatial distribution of dinucleotides, tetranucleotides and methylated CpG impact DNA bendability. They used the measurements to develop a physical model for the sequence and methylation dependence of DNA bendability. […]