Computer program can translate a free-form 2-D drawing into a DNA structure  January 3, 2019 Scaffolded DNA origami offers the unique ability to organize molecules in nearly arbitrary spatial patterns at the nanometer scale, with wireframe designs further enabling complex 2D and 3D geometries with irregular boundaries and internal structures. A team of researchers in the US (MIT, Arizona State University) has developed a fully autonomous procedure to design all DNA staple sequences needed to fold any free-form 2D scaffolded DNA origami wireframe object. The algorithm enables the full autonomy of scaffold routing and staple sequence design with arbitrary network edge lengths and vertex angles. The technique has utility for nanoscale […]