MIT News August 6, 2021 A team of researchers in the US (Harvard University, MIT, Boston Children’s Hospital, Beth Israel Deconus Hospital, Mass General Hospital) has developed a low-cost, self-contained, POC diagnostic called miSHERLOCK (minimally instrumented SHERLOCK) that is capable of concurrent universal detection of SARS-CoV-2 as well as specific detection of the B.1.1.7, B.1.351, or P.1 variants. The miSHERLOCK platform integrates an optimized one-pot SHERLOCK reaction with an RNA paper-capture method compatible with in situ nucleic acid amplification and Cas detection. miSHERLOCK combines instrument-free, built-in sample preparation from saliva, room temperature stable reagents, battery-powered incubation, and simple visual and […]