Phys.org July 4, 2023
Suicide gene therapies and immunotoxins have been investigated for the treatment of tumors by direct cancer cell cytotoxicity. Recent advances in mRNA delivery also demonstrated the potential of mRNA-based vaccines and immune-modulators for cancer therapeutics by utilizing nanocarriers for mRNA delivery. Researchers in Israel designed a bacterial toxin-encoding modified mRNA, delivered by lipid nanoparticles into a B16-melanoma mouse model. They showed that local administration of LNPs entrapping a modified mRNA that encodes for a bacterial toxin, induced significant anti-tumor effects and improved overall survival of treated mice. They proposed mmRNA-loaded LNPs as a new class of anti-tumoral, toxin-based therapy… read more. Open Access TECHNICAL ARTICLE
Schematic and microscopic representation of toxin encoding mmRNA-loaded lipid nanoparticles… Credit: Theranostics 2023; 13(11):3497-3508.Â