Eurekalert June 9, 2021
Due to publication bias, there has been little focus on genes other than well-known signature hypoxia-inducible genes. Therefore, researchers in Japan performed a meta-analysis to identify novel hypoxia-inducible genes. They searched publicly available transcriptome databases to obtain hypoxia-related experimental data, retrieved the metadata, and manually curated it, selected the genes that are differentially expressed by hypoxic stimulation, and evaluated their relevance in hypoxia by performing enrichment analyses. They calculated and evaluated the number of reports and similarity coefficients of each gene to HIF1A, which is a representative gene in hypoxia studies. In this data-driven study, they reported that several genes that were not known to be associated with hypoxia, including the G protein-coupled receptor 146 gene, are upregulated by hypoxic stimulation…read more. Open Access TECHNICAL ARTICLE
Schematic View of Hypoxic Transcriptome Meta-Analysis. Credit: Biomedicines 2021, 9(5), 582Â