Princeton team develops ‘poisoned arrow’ to defeat antibiotic-resistant bacteria

EurekAlert  June 3, 2020
An international team of researchers (USA – Princeton University, Germany) have found a compound, SCH-79797, that can simultaneously puncture bacterial walls and destroy folate within their cells while being immune to antibiotic resistance. This is the first antibiotic that can target Gram-positives and Gram-negatives without resistance, attacking via two different mechanisms within one molecule. They hope that it is generalizable, leading to better antibiotics and new types of antibiotics in the future. Even with extraordinary effort, they were unable to generate any resistance to this compound… read more. TECHNICAL ARTICLE

Graphic abstract. Credit: Cell, June 3, 2020

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