Phys.org September 4, 2024 In 2022, mpox virus (MPXV) spread worldwide, causing 99,581 mpox cases in 121 countries. Modified vaccinia Ankara (MVA) vaccine use reduced disease in at-risk populations but failed to deliver complete protection. Lag in manufacturing and distribution of MVA resulted in additional MPXV spread, and an additional outbreak in Central Africa of clade I virus. A team of researchers in the US (United States Army Medical Research Institute of Infectious Diseases, industry, NIH, Boston University) tested mRNA-1769, an mRNA-lipid nanoparticle (LNP) vaccine expressing MPXV surface proteins, in a lethal MPXV primate model. Similar to MVA, mRNA-1769 conferred […]
Tag Archives: Global health
The Big 3 Infectious Diseases Besides COVID-19 Scientists Are Trying to Find a Vaccine For
Global Biodefense October 5, 2020 Researchers in Australia regard malaria, tuberculosis, and HIV/AIDS as the “big three” infectious diseases. Together they are responsible for about 2.7 million deaths a year around the world. Although anti-malarial drugs are routinely used to treat and prevent malaria infection, the emergence of multi-drug resistant tuberculosis is a major cause of death and a serious public health concern. Since the discovery of HIV in the 1980s, the disease has caused 33 million deaths. Some 38 million people have HIV/AIDS worldwide. There is currently no cure or protective vaccine. The current pandemic highlights the need for […]
Landmark recommendations on development of artificial intelligence and the future of global health
Science Daily May 19, 2020 In this review article, a team of researchers in the US (Columbia University, Johns Hopkins University) suggests that AI-driven health interventions fit into four categories relevant to global health researchers: (1) diagnosis, (2) patient morbidity or mortality risk assessment, (3) disease outbreak prediction and surveillance, and (4) health policy and planning. However, much of the AI-driven intervention research in global health does not describe ethical, regulatory, or practical considerations required for widespread use or deployment at scale. Despite the field remaining nascent, AI-driven health interventions could lead to improved health outcomes in Low and Middle […]