Science Daily September 14, 2021
The reactions in DNA-based combinational logic computing are mostly achieved through a manual process. For DNA-based Boolean logic, researchers in South Korea have fabricated a DNA-based microfluidic processing unit (MPU). They cast polydimethylsiloxane using double-sided molding techniques for alignment between the microfluidics and valve switch. For a uniform surface, molds fabricated using a three-dimensional printer were spin-coated by a polymer. For programming control, the valve switch arms were operated by servo motors. In the MPU controlled via a personal computer or smartphone application, the molecules with two input DNAs and a logic template DNA were reacted for the basic AND and OR operations. The DNA molecules reacted in a cascading manner for combinational AND and OR operations. They demonstrated a 2-to-1 multiplexer and the XOR operation with a three-step cascade reaction using the simple DNA-based MPU, which can perform Boolean logic operations (AND, OR, and NOT). Through logic combination the DNA-based Boolean logic MPU is expected to facilitate the development of complex functional circuits such as arithmetic logical units and neuromorphic circuits…read more. TECHNICAL ARTICLEÂ
Abstract. Credit: ACS Nano 2021, 15, 7, 11644–11654, July 7, 2021Â