Phys.org May 18, 2021
An international team of researchers (USA – University of Florida, Taiwan) has developed a sensor system which amplifies the binding signal for a target biomarker using a disposable and biofunctionalized strips, which can be connected externally to a reusable printed circuit board for signal amplification with an embedded MOSFET. The sensor was externally connected to the gate electrode of the MOSFET, and synchronous pulses were applied to both the sensing strip and the drain contact of the MOSFET. The resulting changes in the dynamics of drain waveforms were converted into analog voltages and digital readouts, which correlate with the concentration of proteins and virus present in the tested solution. A broad range of protein concentrations and virus concentrations from were detectable for the sensor functionalized with both antibodies. The approach paves way for the development of a portable, low-cost, and disposable cartridge sensor system for point-of-care detection of viral diseases…read more. Open Access TECHNICAL ARTICLEÂ
Example MOSFET drain waveform at a fixed gate voltage (1.5 V) for different SARS-CoV-2 spike peptide concentrations in saliva using a test strip functionalized with a SARS-CoV-Spike antibody… Credit: Journal of Vacuum Science & Technology B 39, 033202 (2021)Â