Agents that target viral RNA could be the basis for next generation anti-viral drugs

EurekAlert  May 10, 2021
The technique proposed by a team of researchers in the UK uses cylindrically shaped molecules which can block the function of a particular section at one end of the RNA strand called untranslated RNA that are essential for regulating the replication of the virus. They contain junction points and bulges which are normally recognised by proteins or other pieces of RNA. The cylindrical molecules are attracted to these holes. Once they slide into them, the RNA closes around them, forming a precise fit, which consequently will interfere with the virus’s ability to replicate. According to the researchers they have identified molecules capable of tackling the most fundamental part of the virus – its RNA. Experiments backed up by computer modelling have shown this to be effective against SARS-CoV-2 and the HIV viruses. They anticipate it will also be effective against a wide range of other viruses, offering an important first step towards a broad spectrum anti-viral drug…read more. TECHNICAL ARTICLE