Nanowerk November 25, 2020
Researchers in Germany developed a set of near infrared fluorescent nanosensors are based on single-walled carbon nanotubes that fluoresce in the NIR optical tissue transparency window which offers ultra-low background and high tissue penetration. They are chemically tailored to detect released metabolites as well as specific virulence factors and integrated into functional hydrogel arrays with 9 different sensors. These hydrogels are exposed to clinical isolates of 6 important bacteria and remote (≥25 cm) NIR imaging allows to identify and distinguish bacteria. Sensors are also spectrally encoded to differentiate the two major pathogens P. aeruginosa as well as S. aureus and penetrate tissue (>5 mm). This type of multiplexing with NIR fluorescent nanosensors enables remote detection and differentiation of important pathogens and the potential for smart surfaces…read more. Open Access TECHNICAL ARTICLE