Science Daily September 25, 2020
Researchers at the Colorado State University invented a biosensor that lights up blue when viral translation is happening, and green when normal host translation is happening, in single living cells. They have shown this host-attacking process, at the single-molecule level in living cells, and they have reproduced these behaviors in computational models. The models showed that both healthy human RNA and viral RNA fluctuate between states that actively express proteins and those that are silent. The combination of their sensors and computational analyses provide powerful tools to understand, predict, and control how future drugs might work to inhibit viral translation without affecting host translation…read more. TECHNICAL ARTICLE