Medical Express August 27, 2020
An international team of researchers (Sweden, Ukraine, Spain, Italy) demonstrated that grafted cells integrate into an already established neuronal network, present in a slice of brain cortex from a human donor, receiving inputs and establishing synaptic contacts with the neurons of the slice. The transplantation of cells can be obtained from the same patient, avoiding graft rejection and ethical concerns associated with this kind of therapies…read more. Open Access TECHNICAL ARTICLEÂ
Cortically fated neuroepithelial-like stem (lt-NES) cells, which can form functional synaptic networks in cell culture, differentiate to mature layer-specific cortical neurons when transplanted ex vivo onto organotypic cultures of adult human cortex. Credit: Universidad de Barcelona