Technology.org May 12, 2020
While fluorescence microscopy can provide nano- to microscale resolution, the resolution decreases rapidly along with depth into biological tissue because most biological tissue is opaque. Researchers at Caltech have developed a method that utilizes the correlation between the dynamic speckle-encoded fluorescence and ultrasound-modulated light signal that originate from the same location within a sample. They imaged fluorescent targets with an improved resolution of ≤75 µm (versus a resolution of 1.3 mm with direct optical imaging) within a scattering medium with 17 ms decorrelation time. The new imaging modality paves the way for fluorescence imaging in highly scattering tissue in vivo…read more. TECHNICAL ARTICLE
An artistic illustration of FLUX imaging… Credit: Haowen Ruan and Yan Liu, Caltech