Science Daily May 30, 2019
Exposure to high-dose irradiation (>10 gray) from the uncontrolled release of radioactive materials or intensive radiotherapy for cancer treatment can cause gastrointestinal syndrome (GIS), a lethal disorder affecting the intestinal structure. To assess medical countermeasures, it is essential to develop specific and robust animal models in which the relationship between radiation doses, GIS incidence, and severity can be correlated with the histopathology of the intestine. Researchers in Spain aim to understand cell biology and molecular events of GIS after radiation exposure by using a genetic GIS mouse model generated in their laboratory. This information will help in identifying biomarkers that can predict degrees of intestinal toxicity after severe ionizing radiation and assist in developing procedures to protect against GIS…read more. TECHNICAL ARTICLEÂ