Phys.org November 6, 2018
An international team of researchers (Austria, Canada) has developed a new synthetic approach that allows RNA to be chemically synthesized about a million times more efficiently than previously possible. They adapted the photolithographic fabrication technology from the semiconductor chip industry for the chemical synthesis of RNA. Biological photolithography makes it possible to produce RNA chips with a density of up to one million sequences per square centimeter. Instead of using far ultraviolet light, which is used in the production of computer chips silicon etching and doping, the researchers use UV-A light. The combination of high-synthesis yield and ease of handling makes it possible to foresee the preparation of longer, and functional, RNA molecules on microchips…read more. TECHNICAL ARTICLE
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