Sugar-coated nanosheets developed to selectively target pathogens

Science Daily  March 29, 2018
A team of researchers in the US (Lawrence Berkeley National Laboratory, New York University) created the synthesized nanosheets out of self-assembling, bio-inspired polymers called peptoids. The sheets were designed to present simple sugars in a patterned way along their surfaces. Picking the right sugars to bind to the peptoid nanosheets, in the right distributions, can determine which pathogens will be drawn to them. They confirmed that the bindings with the targeted proteins were successful. The peptoid platform is rugged and stable, it can be deployed into the field for tests of bioagents by military personnel and emergency responders… read more. TECHNICAL ARTICLE

A molecular model of a peptoid nanosheet that shows loop structures in sugars (orange) that bind to Shiga toxin. Credit: Berkeley Lab

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