Science Daily December 10, 2021 A team of researchers in the US (Indiana University, Purdue University, industry, Veterans Administration Medical Center, University of Chicago) has developed a silicon device that can change skin tissue into blood vessels and nerve cells has advanced from prototype to standardized fabrication. The technology, called tissue nano transfection, is a non-invasive nanochip device that can reprogram tissue function by applying a harmless electric spark to deliver specific genes in a fraction of a second. The nanofabrication process typically takes five to six days, and in vivo takes 30 min. In laboratory studies, the device successfully […]
Tag Archives: Regenerative medicine
New biomaterial regrows blood vessels and bone, RCSI research
EurekAlert April 20, 2021 Researchers in Ireland used mechanobiology-informed approach to design a functionalized scaffold for the dose-controlled delivery of PGF which is capable of promoting regeneration of critically sized bone defects. Alginate microparticles and collagen/hydroxyapatite scaffolds were shown to be effective PGF-delivery platforms. Although this PGF-functionalized scaffold demonstrated only a modest increase in osteogenic capacity in vitro, robust bone regeneration was observed after implantation into rat calvarial defects, indicating that the dose-dependent effect of PGF can be harnessed as an alternative to multi-drug systems for the delivery of both pro-angiogenic and pro-osteogenic cues. The research provides a framework for […]