Deadly virus structures point toward new avenues for vaccine design

Science Daily  May 24, 2023 There are currently no widely approved treatments or vaccines for the Lassa virus. An international team of researchers (USA – The Scripps Research Institute, University of Georgia, Tulane University School of Medicine, UK, Germany, the Netherlands) determined the structure of LASV glycoprotein complex (GPC) which mediates viral entry and is the sole target for neutralizing antibodies. Scientists have also struggled to isolate Lassa glycoproteins — the spike-like proteins that surround the virus and are the target of most antibodies. In the infectious virus, these glycoproteins exist in complexes of three, called trimers. For decades, however, […]