Phys.org May 7, 2024 Underwater adhesion processes have faced challenges to uniformly transfer nanoparticles into a monolayer, particularly those below 100 nm in size, over large areas. Researchers in South Korea have developed a scalable “one-shot” self-limiting nanoparticle transfer technique, enabling the efficient transport of nanoparticles from water in microscopic volumes to an entire 2-inch wafer in a remarkably short time of 10 seconds to reach near-maximal surface coverage in a 2D mono-layered fashion. They used proton engineering in electrostatic assembly which accelerated the diffusion of nanoparticles resulting in a hundredfold faster coating speed than the previously reported results in […]
Tag Archives: Nanoparticles
‘Plug and play’ nanoparticles could make it easier to tackle various biological targets
Phys.org October 30, 2023 Despite their inherent versatility and ability to enable complex biological applications, there is considerable interest in augmenting the performance of membrane-coated nanoparticles (CNP) through the introduction of additional functionalities. Researchers at UC San Diego developed and demonstrated a genetic-engineering-based modular approach to CNP functionalization. The cell membrane coating was engineered to express a SpyCatcher membrane anchor that could readily form a covalent bond with any moiety modified with SpyTag. They generated three unique targeted CNP formulations using different classes of targeting ligands, including a designed ankyrin repeat protein. In vitro, the modified nanoparticles exhibited enhanced affinity […]