Phys.org  August 23, 2023 In nature, proteins that switch between two conformations in response to environmental stimuli structurally transduce biochemical information in a manner analogous to how transistors control information flow in computing devices. Designing proteins with two distinct but fully structured conformations is a challenge for protein design as it requires sculpting an energy landscape with two distinct minima. A team of researchers in the US (University of Washington, Lawrence Berkeley National Laboratory, University of Milwaukee) described the design of “hinge” proteins that populate one designed state in the absence of ligand and a second designed state in the […]