Phys.org May 9, 2024 Isoprenol is a precursor for a promising SAF compound DMCO (1,4-dimethylcyclooctane) and is produced in several engineered microorganisms. Recently, Pseudomonas putida has gained interest as a future host for isoprenol bioproduction as it can utilize carbon sources from inexpensive plant biomass. A team of researchers in the US (industry, PNNL, Lawrence Berkeley National Laboratory) engineered metabolically versatile host P. putida for isoprenol production. They employed two computational modeling approaches to predict gene knockout targets and optimize the “IPP-bypass” pathway in P. putida to maximize isoprenol production. Altogether, the highest isoprenol production titer from P. putida was […]
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Engineers find a new way to convert carbon dioxide into useful products
MIT News March 27, 2024 For electrochemical reduction of carbon dioxide with a small-molecule catalyst, the catalyst must be proximal to an electrode surface. Efforts to immobilize molecular catalysts on electrodes have been stymied by the need to optimize the immobilization chemistries on a case-by-case basis. Researchers at MIT applied DNA as a molecular-scale “Velcro” to investigate the tethering of three porphyrin-based catalysts to electrodes improving both the stability of the catalysts and their Faradaic efficiencies (FEs). Immobilization resulted in higher catalyst stability at relevant potentials. Lower overpotentials were required for the generation of CO. High FE for CO generation […]