NIAID July 20, 2022 NIAID and its partners under the Chemical Countermeasures Research Program (CCRP) invite applications for the early-stage development of therapeutics and medical countermeasures (MCMs) to mitigate the adverse health effects resulting from toxic chemical exposure, including validation of therapeutic targets and preclinical characterization of lead compounds. Through the funding opportunity announcement (FOA) CCRP Initiative: Countermeasures Against Chemical Threats (CounterACT) Therapeutics Discovery and Early-Stage Development (UG3/UH3, Clinical Trial Not Allowed), the ultimate aim is to generate well-characterized therapeutic candidates that may one day advance the nation’s medical and public health preparedness for, response to, and recovery from chemical-related […]
Tag Archives: Chemical agents
Protein that could prevent chemical warfare attack created
Phys.org September 1, 2022 The creation of proteins that use specific, sensitive, real-time biological recognition detection methods for VX neurotoxin using directed evolution or library screening methods has been hampered because its toxicity makes laboratory experimentation extraordinarily expensive. A team of researchers in the US (the City College of New York, the State University of New Jersey, Clarkson University) designed the protein to have a cavity at its center that matched the precise shape and chemical composition of VX. The protein underwent a dramatic shape change, burying VX in the cavity. The shape change is the signal which could be […]
Scientists synthesise a MOF capable of degrading nerve agents in water
Nanowerk September 30, 2020 An international team of researchers (Spain, USA – Scripps research, CA, industry, UK, Portugal) used heterometallic metal-organic frameworks to exemplify the advantages of controlling metal distribution across the framework in heterogeneous catalysis by exploring their activity toward the degradation of a nerve agent simulant of Sarin gas. MUV-101(Fe) is the only pristine MOF capable of catalytic degradation of diisopropyl-fluorophosphate (DIFP) in non-buffered aqueous media. This activity cannot be explained only by the association of two metals, but to their synergistic cooperation, to create a whole that is more efficient than the simple sum of its parts. […]